abstract：:Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...

journal_title：Brain research

authors： Shui Y,Wang L,Luo X,Uchiumi O,Yamamoto R,Sugai T,Kato N

更新日期：2015-04-24 00:00:00

abstract：:Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...

journal_title：Brain research

authors： McGuire B,Fiorillo B,Ryugo DK,Lauer AM

更新日期：2015-04-24 00:00:00

abstract：:Tumor suppressor p53 has recently been reported to have numerous functions independent of tumorigenesis, including neuronal survival during ischemia. The mammalian target of rapamycin (mTOR) signaling pathway plays a central role in the regulation of metabolism, cell growth, development, and cell survival. Our recent ...

journal_title：Brain research

authors： Li X,Gu S,Ling Y,Shen C,Cao X,Xie R

更新日期：2015-04-24 00:00:00

abstract：:Gonadotrophin-releasing hormone (GnRH) neurons do not express the leptin receptor (OB-R) in the medial preoptic area (MPOA) and the medial basal hypothalamus (MBH). We assessed whether the effect of leptin on the secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) in proestrus...

journal_title：Brain research

authors： Del Bianco-Borges B,Franci CR

更新日期：2015-04-16 00:00:00

abstract：:Recent studies suggest that selective block of extrasynaptic N-methyl-d-aspartate (NMDA) receptors might protect against neurodegeneration. We recorded whole-cell currents with patch pipettes to characterize the ability of memantine, a low-affinity NMDA channel blocker, to block synaptic and extrasynaptic NMDA recepto...

journal_title：Brain research

authors： Wu YN,Johnson SW

更新日期：2015-04-07 00:00:00

abstract：OBJECTIVES:Neuroprotective benefits of ethanol (EtOH) and normobaric oxygenation (NBO) were previously demonstrated in transient and permanent ischemic stroke. Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be a...

journal_title：Brain research

authors： Geng X,Sy CA,Kwiecien TD,Ji X,Peng C,Rastogi R,Cai L,Du H,Brogan D,Singh S,Rafols JA,Ding Y

更新日期：2015-04-07 00:00:00

abstract：:In tasks involving the learning of verbal or non-verbal sequences, groupings are spontaneously produced. These groupings are generally marked by a lengthening of final elements and have been attributed to a domain-general perceptual chunking linked to working memory. Yet, no study has shown how this domain-general chu...

journal_title：Brain research

authors： Gilbert AC,Boucher VJ,Jemel B

更新日期：2015-04-07 00:00:00

abstract：:Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal pigmental epithelium where DOPA facilitates the pigmentati...

journal_title：Brain research

authors： Fukuda N,Naito S,Masukawa D,Kaneda M,Miyamoto H,Abe T,Yamashita Y,Endo I,Nakamura F,Goshima Y

更新日期：2015-03-30 00:00:00

abstract：:Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a reliable seed-based analysis of the resting-state brain activity to comprehensively delineate the subdivisions of striatal functional connectivity implicated in internet gaming disorder. Amon...

journal_title：Brain research

authors： Hong SB,Harrison BJ,Dandash O,Choi EJ,Kim SC,Kim HH,Shim DH,Kim CD,Kim JW,Yi SH

更新日期：2015-03-30 00:00:00

abstract：:Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...

journal_title：Brain research

authors： Dalgard CL,Jacobowitz DM,Singh VK,Saleem KS,Ursano RJ,Starr JM,Pollard HB

更新日期：2015-03-10 00:00:00

abstract：:Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...

journal_title：Brain research

authors： Finlay JM,Dunham GA,Isherwood AM,Newton CJ,Nguyen TV,Reppar PC,Snitkovski I,Paschall SA,Greene RW

更新日期：2015-03-10 00:00:00

abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene that is characterized by progressive action tremor, gait ataxia, and cognitive decline. Recent studies of mitochondrial dysfunction in FXTAS have suggested that iron dysre...

journal_title：Brain research

authors： Ariza J,Steward C,Rueckert F,Widdison M,Coffman R,Afjei A,Noctor SC,Hagerman R,Hagerman P,Martínez-Cerdeño V

更新日期：2015-02-19 00:00:00

abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...

journal_title：Brain research

authors： Khojasteh F,Nahavandi A,Mehrpouya S,Homberg JR,Mirzamohammadi S,Raufi S,Soleimani M,Barati M

更新日期：2015-01-30 00:00:00

abstract：:Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...

journal_title：Brain research

authors： Nagy A,Eder K,Selak MA,Kalman B

更新日期：2015-01-21 00:00:00

abstract：:Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr...

journal_title：Brain research

authors： Allah Yar R,Akbar A,Iqbal F

更新日期：2015-01-21 00:00:00

abstract：:Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...

journal_title：Brain research

authors： Candela P,Saint-Pol J,Kuntz M,Boucau MC,Lamartiniere Y,Gosselet F,Fenart L

更新日期：2015-01-12 00:00:00

abstract：:We assessed the effects of simulated weightlessness, hindlimb unloading (HU) by 7 days of tail suspension, on noxious mechanically and heat evoked spinal withdrawal reflexes and spinal Fos expression during muscle nociception elicited by intramuscular (i.m.) injection of hypertonic (HT; 5.8%) saline into gastrocnemius...

journal_title：Brain research

authors： Lei J,Pertovaara A,You HJ

更新日期：2015-01-12 00:00:00

abstract：:Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with unknown etiology that is characterized by the development of abnormal vascular networks at the base of the brain. Recent genome-wide studies identified RNF213 as an important MMD susceptibility gene. However, the exact mechanism by which the RN...

journal_title：Brain research

authors： Ito A,Fujimura M,Niizuma K,Kanoke A,Sakata H,Morita-Fujimura Y,Kikuchi A,Kure S,Tominaga T

更新日期：2015-01-12 00:00:00

abstract：:In WAG/Rij rat genetic model of absence epilepsy, the first spike-wave discharges (EEG hallmark of absence epilepsy) are known to appear after puberty, and their incidence increases with age. WAG/Rij rats are known to have a genetic predisposition to absence epilepsy, and further development of epilepsy might be influ...

journal_title：Brain research

authors： Sitnikova E,Rutskova EM,Raevsky VV

更新日期：2015-01-12 00:00:00

abstract：:This study investigated the effects of electrical stimulation with theta burst stimulation (eTBS) on seizure suppression. Optimal parameters of eTBS were determined through open-loop stimulation experiments and then implemented in a close-loop seizure control system. For the experiments, 4-aminopyridine (4-AP) was inj...

journal_title：Brain research

authors： Siah BH,Chiang CC,Ju MS,Lin CC

更新日期：2014-12-17 00:00:00

abstract：:The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza vaccines have been widely recommended for women in any period of gestation. Recent studies have shown that the peripheral adaptive immune system plays an important role ...

journal_title：Brain research

authors： Xia Y,Qi F,Zou J,Yao Z

更新日期：2014-12-10 00:00:00

abstract：:Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in th...

journal_title：Brain research

authors： Nguyen KD,Mowlds D,Lopez IA,Hosokawa S,Ishiyama A,Ishiyama G

更新日期：2014-11-24 00:00:00

abstract：:The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...

journal_title：Brain research

authors： Ha JS,Dho SH,Youm TH,Kwon KS,Park SS

更新日期：2014-11-24 00:00:00

abstract：:Mitochondria critically regulate cytoplasmic Ca(2+) concentration ([Ca(2+)]c), but the effects of sensory neuron injury have not been examined. Using FCCP (1µM) to eliminate mitochondrial Ca(2+) uptake combined with oligomycin (10µM) to prevent ATP depletion, we first identified features of depolarization-induced neur...

journal_title：Brain research

authors： Hogan QH,Sprick C,Guo Y,Mueller S,Bienengraeber M,Pan B,Wu HE

更新日期：2014-11-17 00:00:00

abstract：:A positive association between cardiorespiratory fitness (CRF) and white matter integrity has been consistently reported in older adults. However, it is unknown whether this association exists in adults over 80 with a range of chronic disease conditions and low physical activity participation, which can influence both...

journal_title：Brain research

authors： Tian Q,Simonsick EM,Erickson KI,Aizenstein HJ,Glynn NW,Boudreau RM,Newman AB,Kritchevsky SB,Yaffe K,Harris T,Rosano C,Health ABC study.

更新日期：2014-11-07 00:00:00

abstract：:Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm...

journal_title：Brain research

authors： Bickford JS,Ali NF,Nick JA,Al-Yahia M,Beachy DE,Doré S,Nick HS,Waters MF

更新日期：2014-11-07 00:00:00

abstract：:The thalamic midline/intralaminar complex is part of the higher-order thalamus, which receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways. The midline thalamic nuclei connect with the medial prefrontal cortex and the medial temporal lobe. On the other hand, the intralaminar nuc...

journal_title：Brain research

authors： Silva Ade M,de Santana MA,Morais PL,de Sousa TB,Engelberth RC,Lucena EE,Campêlo CL,Cavalcante JS,Cavalcante JC,Costa MS,do Nascimento ES Jr

更新日期：2014-10-24 00:00:00

abstract：:After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...

journal_title：Brain research

authors： Zhou HX,Li XY,Li FY,Liu C,Liang ZP,Liu S,Zhang B,Wang TY,Chu TC,Lu L,Ning GZ,Kong XH,Feng SQ

更新日期：2014-10-24 00:00:00

abstract：:Notch signaling is a highly conserved pathway that regulates cell fate decisions during embryonic development. We have recently identified that in ischemic stroke, activity of γ-secretase and the resulting Notch activation may endanger neurons by modulating NF-κB and HIF-1α pathways. Notch signaling can also modulate ...

journal_title：Brain research

authors： Cheng YL,Choi Y,Seow WL,Manzanero S,Sobey CG,Jo DG,Arumugam TV

更新日期：2014-10-24 00:00:00

abstract：:Stellate ganglion block (SGB) is a blockade of sympathetic ganglia innervating the head and neck, and is known to function through vasodilation of the target region. However, the effectiveness of SGB in relieving cerebral vasospasm (CVS) through dilation of intracerebral vessels has not been evaluated. The aim of the ...

journal_title：Brain research

authors： Hu N,Wu Y,Chen BZ,Han JF,Zhou MT

更新日期：2014-10-17 00:00:00

abstract：:The synchronization of circadian rhythms in sleep, endocrine and metabolic functions with the environmental light cycle is essential for health, and dysfunction of this synchrony is thought to play a part in the development of many neurological disorders. There is a demonstrable need to develop new therapeutics for th...

journal_title：Brain research

authors： Gannon RL

更新日期：2014-10-17 00:00:00

abstract：:The distinction between neural mechanisms of explicit and implicit expressions of memory has been well studied at the retrieval stage, but less at encoding. In addition, dissociations obtained in many studies are complicated by methodological difficulties in obtaining process-pure measures of different types of memory...

journal_title：Brain research

authors： Meng Y,Ye X,Gonsalves BD

更新日期：2014-10-17 00:00:00

abstract：:A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins. Through regulated prion-like assembly, RNA binding prote...

journal_title：Brain research

authors： Ash PE,Vanderweyde TE,Youmans KL,Apicco DJ,Wolozin B

更新日期：2014-10-10 00:00:00

abstract：:A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves th...

journal_title：Brain research

authors： Mohan A,Goodwin M,Swanson MS

更新日期：2014-10-10 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in NOTCH3 may be the primary molecular abnormality in CADASIL. Thus...

journal_title：Brain research

authors： Zhang X,Lee SJ,Young KZ,Josephson DA,Geschwind MD,Wang MM

更新日期：2014-10-02 00:00:00

abstract：:Size matched male green anoles (Anolis carolinensis) were paired in a neutral setting and allowed to engage in aggressive displays. Winners and losers were apparent in each pair within 90min, resulting in stable dominant/subordinate dyads. Androgen receptor (AR) expression was assessed at three time points after the i...

journal_title：Brain research

authors： Hattori T,Wilczynski W

更新日期：2014-09-25 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...

journal_title：Brain research

authors： Pruitt D,Hays S,Schmid A,Choua C,Kim L,Trieu J,Kilgard MP,Rennaker RL 2nd

更新日期：2014-09-25 00:00:00

abstract：:Activity of second-order relay neurons in the nucleus tractus solitarius (NTS) is regulated by peripheral and intrinsic synaptic inputs, and modulation of those inputs by metabotropic glutamate receptors (mGluRs) has been proposed. This study investigated effects of mGluR activation on glutamatergic transmission in th...

journal_title：Brain research

authors： Ohi Y,Kimura S,Haji A

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study analyzed whether administration of sulindac, a non-steroidal anti-inflammatory drug (NSAID) would prevent, attenuate or repair ischemia induced brain injury and reverse functional impairment in a focal ischemia model of stroke. METHODS:Male Sprague-Dawley rats (weight 250-300 g...

journal_title：Brain research

authors： Modi JP,Gharibani PM,Ma Z,Tao R,Menzie J,Prentice H,Wu JY

更新日期：2014-08-12 00:00:00

abstract：:Deferoxamine (DFO) has shown therapeutic promise for the treatment of Parkinson׳s disease (PD) as it has reduced both behavioral and biochemical deficits when injected into the brain of rodent models of PD. Intranasally administered DFO targets the brain directly but non-invasively and has been effective in animal mod...

journal_title：Brain research

authors： Fine JM,Forsberg AC,Renner DB,Faltesek KA,Mohan KG,Wong JC,Arneson LC,Crow JM,Frey WH 2nd,Hanson LR

更新日期：2014-07-29 00:00:00